IS CARICA PAPAYA JUICE A NEW DRUG CANDIDATE AGAINST DENGUE DISEASE?

Carica papaya leaf juice shows potential as a supportive therapy against dengue, improving platelet count and reducing illness severity.

WHAT IS DENGUE?

Dengue is a mosquito-borne viral infection that continues to be a global health concern, particularly in tropical and subtropical regions. When an Aedes aegypti mosquito bites an infected person, it acquires the virus. Later, when the same mosquito bites a healthy person, the virus is transmitted resulting in a dengue infection.

SYMPTOMS OF DENGUE INFECTION

The symptoms usually appear suddenly and may vary in severity. Common signs include:

• High fever

• Rash

• Severe headache

• Joint and muscular pain

• Nausea and vomiting

• Eye pain

• Thrombocytopenia (low platelet count)

• Hemorrhage

WHAT IS DENGUE VIRUS (DENV)?

The dengue virus (DENV) belongs to the Flaviviridae family and consists of four distinct serotypes (DENV-1, DENV-2, DENV-3, and DENV-4). Each serotype can cause infection, and infection with one does not protect against the others.

WHEN DO DENGUE SYMPTOMS APPEAR?

Typically, 5–7 days after being bitten by an infected mosquito, symptoms of dengue infection begin to appear.

CLASSIFICATION OF DENGUE FEVER

To understand the disease progression, dengue fever can be classified into two main types:

• Primary Infection: This occurs when a person is infected with one serotype of the dengue virus. The body develops lifelong immunity against that particular serotype. Generally, dengue fever (DF) is self-limiting and rarely fatal.

• Secondary Infection: If a person who previously had dengue is infected by another serotype, it can result in dengue hemorrhagic fever (DHF) a more severe and potentially fatal form of the disease.

IS THERE ANY TREATMENT AVAILABLE FOR DENGUE VIRUS INFECTION?

At present, no specific antiviral treatment exists for dengue infection. However, several management strategies aim to relieve symptoms and prevent complications.

• Licensed Vaccine: A licensed dengue vaccine is available, but it’s not effective for all serotypes and not suitable for all age groups. Moreover, individuals who have never been exposed to DENV are at a higher risk of developing severe dengue after vaccination. Fortunately, research is ongoing, and a safe tetravalent vaccine is currently under clinical trials.

• Antiviral Medicines: There are no specific antiviral drugs approved for dengue at this time.

• Symptomatic Treatment: Patients are often treated with acetaminophen to manage fever and pain. However, NSAIDs, aspirin, and corticosteroids should be avoided as they can increase the risk of bleeding. In hospital settings, fluid replacement therapy is essential to prevent dehydration and shock.

PATHOGENESIS OF DENGUE INFECTION

The dengue virus primarily affects the bone marrow, suppressing its activity. This results in anemia and hemorrhage due to reduced platelet production.

Additionally, the DENV binds to platelets, which are then mistakenly identified as foreign by the immune system. This immune reaction leads to platelet destruction, causing a decline in platelet count.

Furthermore, DENV also infects vascular endothelial cells, leading to platelet aggregation at the infection site. The immune system then destroys these aggregates, further contributing to low platelet counts and bleeding complications.

CAN CARICA PAPAYA JUICE BE A NEW DRUG CANDIDATE AGAINST DENGUE INFECTION?

In recent years, Carica papaya has gained worldwide attention for its potential therapeutic role against dengue virus infection. Several case studies conducted in Pakistan, India, Bangladesh, and Malaysia have reported its effectiveness in improving platelet counts and reducing the severity of hemorrhage.

Flavonoids and phenolic acids present in papaya leaves are believed to be responsible for these beneficial effects. In fact, it has become a common traditional practice in South Asia to consume papaya leaf juice or extract to help raise platelet levels during dengue.

CARICA PAPAYA: RICH IN MEDICINAL INGREDIENTS

leaves contain an impressive array of bioactive compounds such as carotenoids, carbohydrates, minerals, vitamins, amino acids, saponins, organic acids, alkaloids, phenolic acids, phytochemicals, and flavonoids. These compounds are known for their antioxidant, anti-inflammatory, and immunomodulatory properties.

WHAT IS PAPAYA LEAF JUICE?

Papaya leaf juice is a liquid extract obtained by blending, crushing, pounding, cutting, squeezing, or pressing the leaves of the Carica papaya plant. The resulting juice is bitter but packed with natural medicinal properties.

DOSING OF CARICA PAPAYA JUICE

While there is no universally established dosage, various case studies suggest the following:

• Adults: 30 mL three times daily

• Children: 5–10 mL three times daily

It can be consumed from the first day of fever and continued until recovery. To mask its bitterness, the juice can be mixed with sucrose or milk.

HOW DOES CARICA PAPAYA JUICE WORK Ag3ainst DENGUE INFECTION?

The effectiveness of papaya leaf juice can be explained through several possible mechanisms:

1. Larvicidal Effects

The Aedes mosquito goes through four life stages egg, larva, pupa, and adult. Within 10 days, larvae can mature into adult mosquitoes. Interestingly, papaya leaf extract has shown insecticidal activity against larvae, thereby helping control mosquito populations and preventing disease transmission.

2. Anti-Thrombocytopenic Activity

Papaya leaf juice helps inhibit excessive platelet aggregation, normalizing clotting and bleeding times. This indicates that it may possess anti-thrombocytopenic properties, reducing the risk of hemorrhage.

3. Immunomodulatory Effects

Rich in antioxidants, papaya leaf juice supports immune function by enhancing phagocytic activity and cytokine production, both of which play crucial roles in inflammation and defense against infections.

CONCLUSION

Although extensive clinical research is still needed to confirm the antiviral and anti-thrombocytopenic potential of Carica papaya, the evidence so far is promising. Multiple case studies suggest that papaya leaf juice can:

• Increase platelet count

• Reduce bleeding and fluid leakage

• Shorten the duration of fever

• Prevent progression from DF to DHF

• Lessen hospital stay and overall illness duration

These findings highlight the possibility that Carica papaya leaf juice may one day emerge as a novel, natural drug candidate against dengue virus infection.

FAQs

1. Can papaya leaf juice cure dengue?
No, it cannot cure dengue completely. It may, however, help improve platelet count and reduce disease severity as a supportive remedy.

2. When should papaya juice be started during dengue?
It can be taken from the first day of fever to help prevent complications.

3. Is papaya leaf juice safe for everyone?
Generally, it is safe in small doses, but people with allergies, liver issues, or pregnancy should consult a doctor before using it.

4. Can papaya leaf juice prevent dengue?
No scientific evidence confirms prevention. It may have larvicidal effects that reduce mosquito populations but should not replace preventive measures like mosquito control and repellents.

DISCLAIMER

This article is for educational purposes only and not a substitute for professional medical advice. Always consult a qualified healthcare provider before using herbal or natural remedies for any medical condition.

CALL TO ACTION

If you found this article helpful, share it to raise awareness about natural approaches to dengue management. Stay informed, stay protected, and support research into potential natural treatments like Carica papaya.

REFERENCES

1. Subenthiran S, et al. “Carica papaya Leaves Juice Significantly Accelerates the Rate of Increase in Platelet Count among Patients with Dengue Fever and Dengue Haemorrhagic Fever.” Evidence-Based Complementary and Alternative Medicine, 2013.

2. Ahmad N, et al. “Carica Papaya Linn: An Emerging Plant in the Management of Dengue.” Asian Pacific Journal of Tropical Biomedicine, 2011. 3. Rajapakse S. “Papaya Leaf Extract in Dengue Fever: Is There Any Evidence?” Journal of Ayurveda and Integrative Medicine, 2021.

147 Comments

  5. Everything information about medication. Read here. [url=https://avodart.science/#]where can i buy generic avodart price[/url]
    safe and effective drugs are available. Long-Term Effects.

  9. I was suggested this web site by my cousin. I am
    not sure whether this post is written by him as nobody else
    know such detailed about my problem. You’re amazing!

    Thanks!

  10. Excellent blog you have got here.. It’s hard to find excellent writing
    like yours nowadays. I honestly appreciate people like you!

    Take care!!

  11. I do not even know how I finished up right here, however I thought this submit was great.
    I don’t recognize who you’re but definitely you’re going to a famous blogger if you happen to are not already.

    Cheers!

  15. You’re so cool! I do not suppose I’ve truly read through something
    like that before. So good to find somebody with a few unique thoughts on this issue.
    Really.. many thanks for starting this up. This website is something that is required on the internet, someone with a
    bit of originality!

  16. I’m not sure exactly why but this web site is loading very slow for me.
    Is anyone else having this issue or is it a problem on my end?
    I’ll check back later on and see if the problem still exists.

  18. You can certainly see your enthusiasm in the article you
    write. The sector hopes for more passionate writers such as you who aren’t
    afraid to say how they believe. Always follow your heart.

  19. My spouse and I stumbled over here coming from a
    different website and thought I might check things out.
    I like what I see so now i am following you. Look forward to
    looking over your web page for a second time.

  22. Hi there! I know this is kinda off topic but I was wondering which blog platform
    are you using for this site? I’m getting fed up of WordPress because I’ve had issues with hackers and I’m looking at
    options for another platform. I would be great if you could point
    me in the direction of a good platform.

  25. Today, while I was at work, my cousin stole
    my apple ipad and tested to see if it can survive a twenty five foot drop,
    just so she can be a youtube sensation. My iPad is now destroyed and she has
    83 views. I know this is completely off topic but I had to share it
    with someone!

  26. Please let me know if you’re looking for a author
    for your blog. You have some really great
    articles and I think I would be a good asset. If you ever want to take some of the load
    off, I’d absolutely love to write some material for your blog in exchange for a link
    back to mine. Please send me an e-mail if interested.

    Cheers!

  27. Thank үou so much pertaining t᧐ giving my family ɑn update оn this subject
    on үouг web site. Ⲣlease realise tһat if a fresh post appears or if аny improvements occur аbout
    the current post, І wօuld c᧐nsider reading mⲟre and knowing һow to make
    good utilization of thoѕe methods you share. Ꭲhanks for your time and consideration of other individuals by mаking tһis blog available.

  28. I do not even understand how I finished up here, but I believed this post was great.
    I don’t know who you’re but definitely you are going to a famous blogger when you
    aren’t already. Cheers!

  29. First off I would like to say excellent blog! I had a quick question which I’d like
    to ask if you don’t mind. I was curious to find out how you center yourself and clear
    your mind prior to writing. I’ve had difficulty clearing my thoughts in getting my ideas out.
    I truly do take pleasure in writing but it just seems
    like the first 10 to 15 minutes are generally lost just trying to figure out
    how to begin. Any recommendations or tips? Thank you!

  30. I do not even know how I ended up here, but I thought this
    post was great. I don’t know who you are but definitely
    you’re going to a famous blogger if you are not already 😉
    Cheers!

  32. Hi, i read your blog occasionally and i own a similar one and i was
    just curious if you get a lot of spam remarks? If so how do you reduce it, any
    plugin or anything you can recommend? I get so much lately
    it’s driving me mad so any support is very much appreciated.

  34. Hello! I could have sworn I’ve been to this website before
    but after going through many of the articles I realized it’s new to me.
    Regardless, I’m definitely pleased I came across it and I’ll be book-marking it and checking back frequently!

  37. Hello there! This is my 1st comment here so I just wanted to give a quick shout out and say I really enjoy reading your posts.
    Can you suggest any other blogs/websites/forums that
    cover the same topics? Many thanks!

  39. Simply wish to say your article is as astounding.
    The clearness for your publish is just cool and that i can suppose you are
    knowledgeable on this subject. Fine along with your permission allow me to take hold of your RSS feed to stay up to
    date with forthcoming post. Thank you one million and please
    carry on the gratifying work.

  42. I am really enjoying the theme/design of your weblog. Do you ever run into any browser compatibility problems?
    A few of my blog visitors have complained about my blog not working correctly in Explorer but looks great in Safari.
    Do you have any recommendations to help fix this issue?

  43. Thank you for every other great article. Where else may anyone get that kind of information in such an ideal approach of
    writing? I’ve a presentation next week, and I am at the search for such information.

  44. Its like you read my mind! You appear to know a lot about this, like you
    wrote the book in it or something. I think that you could do with a few pics to drive the message home
    a bit, but other than that, this is fantastic blog.
    An excellent read. I will certainly be back.

  45. Pretty section of content. I just stumbled upon your weblog and in accession capital to assert that I get actually enjoyed account
    your blog posts. Any way I will be subscribing to your feeds and even I achievement you access consistently rapidly.

  46. I have been browsing online more than 4 hours today, yet I
    never found any interesting article like yours.

    It’s pretty worth enough for me. In my opinion, if all website owners and
    bloggers made good content as you did, the web will be
    a lot more useful than ever before.

  47. Hi! Do you know if they make any plugins to safeguard against hackers?
    I’m kinda paranoid about losing everything I’ve worked hard on. Any recommendations?

  48. Thanks on your marvelous posting! I seriously enjoyed reading
    it, you are a great author. I will remember to bookmark your
    blog and will often come back very soon. I want to encourage
    yourself to continue your great work, have a nice holiday weekend!

  49. Thanks for a marvelous posting! I seriously enjoyed reading it, you might
    be a great author. I will always bookmark your blog and will eventually
    come back in the future. I want to encourage continue your
    great posts, have a nice afternoon!

  51. I think everything typed was very reasonable. But, think
    about this, what if you were to write a awesome headline?
    I am not suggesting your content isn’t good, however suppose you added a title to possibly get
    people’s attention? I mean IS CARICA PAPAYA JUICE  HAS THE  POTENTIAL TO BE NEW DRUG CANDIDATE AGAINST DENGUE DISEASE  – Pharma Healths is
    kinda vanilla. You should glance at Yahoo’s front page and watch
    how they create article titles to grab people to
    click. You might add a related video or a picture or two to get people excited about what you’ve written. In my opinion, it would bring your posts a little livelier.

  52. Hey! I understand this is kind of off-topic but
    I needed to ask. Does building a well-established website like yours require a large amount of work?
    I’m brand new to running a blog however I do write in my diary everyday.

    I’d like to start a blog so I will be able to share my personal experience and
    thoughts online. Please let me know if you have any suggestions or tips for new aspiring bloggers.
    Thankyou!

  55. Can I simply say what a comfort to discover somebody that actually understands what they’re talking about on the web.

    You certainly understand how to bring an issue to light and make it
    important. A lot more people should look at this and understand this side of your story.
    I can’t believe you are not more popular given that you surely
    possess the gift.

  56. For hottest news you have to go to see web and
    on internet I found this site as a most excellent website for most up-to-date updates.

  57. I all the time used to study piece of writing in news papers but now
    as I am a user of web so from now I am using net for articles or reviews, thanks to
    web.

  58. I loved as much as you will receive carried out right
    here. The sketch is attractive, your authored material stylish.
    nonetheless, you command get bought an edginess over that you wish
    be delivering the following. unwell unquestionably
    come further formerly again as exactly the same nearly very
    often inside case you shield this increase.

  59. Good day I am so excited I found your website, I really found you
    by mistake, while I was searching on Bing for
    something else, Regardless I am here now and would just like to say
    many thanks for a fantastic post and a all round exciting
    blog (I also love the theme/design), I don’t have time to read
    it all at the moment but I have saved it and also included your RSS feeds, so when I have time I will be back to read
    more, Please do keep up the fantastic job.

  60. Hi there, I discovered your website by way of Google at the
    same time as looking for a similar subject, your website got here up, it looks great.
    I’ve bookmarked it in my google bookmarks.
    Hi there, simply became aware of your weblog through Google, and located that it is truly informative.

    I am going to be careful for brussels. I will appreciate in case you proceed this
    in future. Numerous other folks can be benefited out of your
    writing. Cheers!

  62. I enjoy what you guys tend to be up too. This sort of clever work and exposure!
    Keep up the great works guys I’ve included you guys to blogroll.

  64. Wonderful blog! I found it while surfing around on Yahoo News.
    Do you have any tips on how to get listed in Yahoo News?
    I’ve been trying for a while but I never seem to get there!
    Appreciate it

  67. Have you ever thought about including a little bit more than just
    your articles? I mean, what you say is fundamental and everything.
    But just imagine if you added some great graphics
    or video clips to give your posts more, “pop”! Your
    content is excellent but with images and video clips, this site could definitely be one of the
    best in its field. Great blog!

  68. I really like what you guys are usually up too.
    This sort of clever work and coverage! Keep up the amazing works
    guys I’ve incorporated you guys to my own blogroll.

  69. Thanks for another informative site. The place else may
    I am getting that type of info written in such a perfect approach?

    I have a venture that I am just now operating on, and
    I’ve been at the glance out for such information.

  74. Hi there! I just wanted to ask if you ever have any problems
    with hackers? My last blog (wordpress) was hacked and
    I ended up losing a few months of hard work due to no data backup.
    Do you have any solutions to stop hackers?

  76. Hello There. I found your blog using msn. This is a really well written article.

    I will make sure to bookmark it and return to read more of your
    useful information. Thanks for the post. I will definitely return.

  78. I do not know whether it’s just me or if perhaps everybody else experiencing issues
    with your site. It appears as if some of the
    text on your content are running off the screen. Can someone else please
    provide feedback and let me know if this is happening to them too?

    This may be a problem with my web browser because I’ve had
    this happen previously. Thanks

  79. Having read this I thought it was very informative. I appreciate you finding the time and effort to put this content together.
    I once again find myself personally spending a significant
    amount of time both reading and commenting. But so what, it was still worthwhile!

  81. I have been surfing online more than three hours today, yet I never found any interesting article like yours.
    It is pretty worth enough for me. Personally, if all website owners and
    bloggers made good content as you did, the net will be much
    more useful than ever before.

  83. Does your website have a contact page? I’m having trouble locating it but,
    I’d like to send you an email. I’ve got some creative ideas for
    your blog you might be interested in hearing. Either way, great website and I look forward to seeing it develop over time.

  87. When I originally commented I clicked the “Notify me when new comments are added” checkbox and now each time a comment is added I get four e-mails with the same comment.
    Is there any way you can remove me from that service?
    Thanks!

  88. Howdy! This is my 1st comment here so I just wanted to give a quick shout out and say I genuinely
    enjoy reading your posts. Can you recommend any other blogs/websites/forums that cover the same topics?
    Appreciate it!

  91. Wow that was odd. I just wrote an really long comment but after I clicked submit
    my comment didn’t show up. Grrrr… well I’m not writing all that over again. Regardless, just wanted to say great blog!

  97. Fantastic items from you, man. I’ve have in mind your stuff
    prior to and you’re just extremely wonderful. I actually like what you have bought here,
    certainly like what you are stating and the way in which through which
    you say it. You are making it entertaining and you
    continue to care for to keep it wise. I cant wait to
    read far more from you. This is actually a terrific
    website.

  98. I must thank you for the efforts you’ve put in penning this site.
    I really hope to see the same high-grade blog posts by you
    in the future as well. In fact, your creative writing abilities has encouraged me to get my very own blog now 😉

  100. You can definitely see your expertise within the work you write.
    The world hopes for even more passionate writers like you who are not afraid to say how they believe.
    All the time follow your heart.

  101. Hello there! Do you know if they make any plugins to help with
    SEO? I’m trying to get my blog to rank for some targeted
    keywords but I’m not seeing very good results.
    If you know of any please share. Appreciate it!

  102. Can I simply just say what a comfort to find somebody that actually understands what they’re talking
    about on the internet. You definitely understand how to bring a problem to light and make it
    important. More people should look at this and understand
    this side of the story. I was surprised that you aren’t
    more popular since you certainly have the gift.

  103. Undeniably believe that which you said. Your favorite reason appeared to be on the web the easiest thing to be aware of. I say to you, I definitely get irked while people consider worries that they just do not know about. You managed to hit the nail upon the top and also defined out the whole thing without having side effect , people could take a signal. Will probably be back to get more. Thanks

  104. Hey I know this is off topic but I was wondering if you knew of any widgets I could add to my blog that automatically tweet my newest twitter updates. I’ve been looking for a plug-in like this for quite some time and was hoping maybe you would have some experience with something like this. Please let me know if you run into anything. I truly enjoy reading your blog and I look forward to your new updates.

  105. I am really loving the theme/design of your website. Do you ever run into any web browser compatibility issues?
    A few of my blog readers have complained about my website not working correctly in Explorer but looks great in Safari.
    Do you have any ideas to help fix this problem?

  109. I believe that is among the most significant info for me.
    And i am happy studying your article. But want
    to remark on few general issues, The site taste is great,
    the articles is actually nice : D. Just right
    activity, cheers

  110. Heya i am for the first time here. I came across
    this board and I find It truly useful & it helped me out a lot.
    I’m hoping to offer something again and aid others such as you aided me.

  111. This is very attention-grabbing, You are an overly professional
    blogger. I’ve joined your rss feed and look forward to looking for
    more of your excellent post. Also, I’ve shared your website in my social networks

  115. I’m amazed, I have to admit. Rarely do I come across a blog that’s equally educative and amusing, and
    without a doubt, you’ve hit the nail on the head.
    The problem is something that too few folks are speaking intelligently about.
    Now i’m very happy that I found this in my search
    for something concerning this.

  117. Heya just wanted to give you a brief heads up and let you know a few of
    the pictures aren’t loading correctly. I’m not sure why but I think its a linking issue.
    I’ve tried it in two different browsers and both show the same results.

  119. naturally like your web site however you need to take a look at the spelling on several of your posts. A number of them are rife with spelling problems and I find it very bothersome to tell the truth on the other hand I will surely come again again.

  121. Hi, i think that i saw you visited my website so i came to
    “return the favor”.I am attempting to find things
    to enhance my website!I suppose its ok to use some of your ideas!!

  126. My brother suggested I would possibly like this blog. He was entirely right.

    This post truly made my day. You cann’t imagine just how
    much time I had spent for this info! Thanks!

  128. Greetings from Ohio! I’m bored at work so I decided to browse your site on my iphone during lunch break.
    I really like the information you provide
    here and can’t wait to take a look when I get home.
    I’m shocked at how quick your blog loaded on my mobile ..

    I’m not even using WIFI, just 3G .. Anyways, awesome blog!

  136. Aw, this was an exceptionally good post. Taking a few minutes and actual effort to make
    a top notch article… but what can I say… I hesitate a whole lot and never manage to get nearly anything done.

  137. Good day very nice website!! Man .. Excellent ..
    Wonderful .. I’ll bookmark your website and take the feeds also?
    I’m glad to find so many helpful info right here in the post, we’d
    like work out more strategies in this regard, thank you for sharing.
    . . . . .

  138. I blog often and I seriously appreciate your content. This great
    article has really peaked my interest. I am going to take a note of your website and keep checking for
    new information about once per week. I opted in for your Feed too.

  142. I like the helpful information you provide in your articles.

    I will bookmark your weblog and check again here frequently.
    I am quite certain I will learn plenty of new stuff right here!

    Good luck for the next!

Leave a Reply

Your email address will not be published. Required fields are marked *

Trending now

WHICH ONE IS CARCINOGENIC? DEFICIENCY OF VITAMIN A OR DIETARY BETA CAROTENE OR SUPPLEMENTS OF BETA CAROTENE?
IS CARICA PAPAYA JUICE A NEW DRUG CANDIDATE AGAINST DENGUE DISEASE?
GLOBAL HANDWASHING DAY: WHY REGULAR SOAP WORKS BETTER THAN ANTIBACTERIAL SOAPS
WALKING GUIDELINES FOR DIABETIC PATIENTS