Tag antidepressant pharmacology

Learn how antidepressant pharmacology works, including drug mechanisms, neurotransmitter effects, and how medications help manage depression symptoms.

Mental Health

Why Antidepressants Stop Working: SSRI Resistance and Tolerance Explained

Why antidepressants stop working over time: an explanation of SSRI resistance, antidepressant tolerance, brain adaptation, and treatment options.

SSRIs can lose effectiveness over time — and there are real biological reasons why. A pharmacist explains antidepressant tachyphylaxis, SSRI resistance, and your best clinical options.

Aisha Saleem
July 8, 2026

Why Antidepressants Stop Working: SSRI Resistance and Tolerance Explained

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